If you're looking for luxury in Italy, Rome is a good place for luxurious grand hotels. Since Rome was a stop on the European Grand Tour of the late 1900's, several grand hotels opened to serve Grand Tour travelers. Today several of these elegant hotels have been renovated and still offer luxury digs for those who want an Italian vacation in style. 
The Hotel Eden (see review), a popular hotel in the Grand Tour era, is a good luxury choice with fantastic views of Rome. Here are more Top Rated Luxury Hotels in Rome.
More Places to Stay in Rome:
- Top Historic Center Hotels
- Top Hotels Near Termini Station
- Top Rome Budget Hotels
- My Rome Recommendations - Places I've Stayed
View of Rome from Hotel Eden Guest Room © James Martin, Europe Travel
The hotel really exudes that warm Italian vibe. Looks so cozy and I bet the food is great too. A good combination for a leisurely luxury vacation.