Pope Benedict XVI gave his final Sunday blessing on Sunday to a huge crowd in Saint Peter's Square and Wednesday's Papal Audience at 10:30 AM, also expected to draw a huge crowd, will be his final appearance before his resignation (see Pope Announces Resignation). Huge crowds are expected for Papal Audiences once the new Pope is chosen and for the usual Easter week events presided over by the Pope. If you want to go to a Papal audience you'll need to reserve a ticket. While there is no cost for the ticket, it can be a little difficult to arrange yourself (see How to Request an Audience with the Pope). Select Italy offers ticket reservations for a fee if you don't want to do it yourself.
Big crowds at the Vatican means that Rome will be very crowded. If you're planning to go to Rome this spring, reserve a hotel in advance, especially if you want a hotel near Vatican City - for more choices see Top Places to Stay in Rome.
Palm Sunday in Saint Peter's Square, photo by Doug Baumgart, used by permission