From Piazza San Domenico Maggiore, walk along Via San Biago. This street is known as Spaccanapoli because it splits the old center of Naples in half. The original Greek city of Neapolis was here and the area still retains the same narrow streets from Greek times. Spaccanapoli was one of the three main east-west Greek streets.
Stop in the Church of Sant'Angelo a Nilo to see the bas relief on the tomb of the tomb of Cardinal Brancacci by Donatello and Michelozzo and paintings by Marco Pino. Near the church in the small square, Piazzetta del Nilo, you'll see a large marble Roman statue dedicated to the Nile River.
Pastry Stop: Scaturchio, known as one of the best pasty shops. Try the sfogliatelle or babba, typical pastries of Naples.
Continue along Spaccanapoli, doing a little window shopping, until you arrive at Via San Gregorio Armeno.