Campo dei Fiori, Trastevere, and Jewish Ghetto
Campo dei Fiori is alive in the mornings with a market and flower vendors so it makes an interesting start to your day. From there wander along the Tiber River to Ponte Sisto, cross the Tiber to the Trastevere neighborhood and visit the church of Santa Maria in Trestevere (picture), Rome's first Christian church. Cross back to the other side and continue to the Jewish Ghetto. There are several places to sample Rome's interesting Jewish cuisine in the Ghetto.
Tip: If you're up early and want good photos of Piazza Navona, start the itinerary there, before the tourists arrive. Then continue to Campo dei Fiori.
Capitoline Hill Museums
From the busy Piazza Venezia, a transport hub and home to the Vittorio Emanuele Monument, go up to the Capotoline Hill, where you will have a fabulous view of the Roman Forum. The piazza was designed by Michelangelo and the museums are the oldest in the world. Palazzo Nuovo has Greek and Roman sculptures and Palazzo dei Conservatori has art galleries, sculptures, and frescoes. A ticket is good for both. Capitoline Museums
Tonight go to the Testaccio District by taxi, bus 75 or the metro. You'll want to make a reservation for dinner at Checchino dal 1887, a very nice restaurant serving old Roman cuisine. The Testaccio District has several good night clubs if you want to go out after dinner.
Tip: Be alert for pickpockets on the Metro and in crowds.